Emerging and evolving concepts in gene essentiality

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  • Additional Information
    • Publication Information:
      Nature Publishing Group
    • Publication Date:
      2018
    • Abstract:
      Author(s): Giulia Rancati [1]; Jason Moffat [2, 3]; Athanasios Typas [4]; Norman Pavelka (corresponding author) [5] Some genomes may contain >100,000 protein-coding genes [1], but which are really indispensable for [...]
      Gene essentiality is a founding concept of genetics with important implications in both fundamental and applied research. Multiple screens have been performed over the years in bacteria, yeasts, animals and more recently in human cells to identify essential genes. A mounting body of evidence suggests that gene essentiality, rather than being a static and binary property, is both context dependent and evolvable in all kingdoms of life. This concept of a non-absolute nature of gene essentiality changes our fundamental understanding of essential biological processes and could directly affect future treatment strategies for cancer and infectious diseases.
    • ISSN:
      1471-0056
    • Accession Number:
      10.1038/nrg.2017.74
    • Rights:
      Copyright 2018 Gale, Cengage Learning. All rights reserved.
      COPYRIGHT 2018 Nature Publishing Group
    • Accession Number:
      edsgcl.518394465
  • Citations
    • ABNT:
      RANCATI, G. et al. Emerging and evolving concepts in gene essentiality. Nature Reviews Genetics, [s. l.], n. 1, p. 34, 2018. Disponível em: . Acesso em: 11 nov. 2019.
    • AMA:
      Rancati G, Moffat J, Typas A, Pavelka N. Emerging and evolving concepts in gene essentiality. Nature Reviews Genetics. 2018;(1):34. doi:10.1038/nrg.2017.74.
    • APA:
      Rancati, G., Moffat, J., Typas, A., & Pavelka, N. (2018). Emerging and evolving concepts in gene essentiality. Nature Reviews Genetics, (1), 34. https://doi.org/10.1038/nrg.2017.74
    • Chicago/Turabian: Author-Date:
      Rancati, Giulia, Jason Moffat, Athanasios Typas, and Norman Pavelka. 2018. “Emerging and Evolving Concepts in Gene Essentiality.” Nature Reviews Genetics, no. 1: 34. doi:10.1038/nrg.2017.74.
    • Harvard:
      Rancati, G. et al. (2018) ‘Emerging and evolving concepts in gene essentiality’, Nature Reviews Genetics, (1), p. 34. doi: 10.1038/nrg.2017.74.
    • Harvard: Australian:
      Rancati, G, Moffat, J, Typas, A & Pavelka, N 2018, ‘Emerging and evolving concepts in gene essentiality’, Nature Reviews Genetics, no. 1, p. 34, viewed 11 November 2019, .
    • MLA:
      Rancati, Giulia, et al. “Emerging and Evolving Concepts in Gene Essentiality.” Nature Reviews Genetics, no. 1, 2018, p. 34. EBSCOhost, doi:10.1038/nrg.2017.74.
    • Chicago/Turabian: Humanities:
      Rancati, Giulia, Jason Moffat, Athanasios Typas, and Norman Pavelka. “Emerging and Evolving Concepts in Gene Essentiality.” Nature Reviews Genetics, no. 1 (2018): 34. doi:10.1038/nrg.2017.74.
    • Vancouver/ICMJE:
      Rancati G, Moffat J, Typas A, Pavelka N. Emerging and evolving concepts in gene essentiality. Nature Reviews Genetics [Internet]. 2018 [cited 2019 Nov 11];(1):34. Available from: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgao&AN=edsgcl.518394465&authtype=sso&custid=s1007886